Cure PhosphoLambaN induced cardiomyopathy (CURE-PLaN)

Cure PhosphoLambaN induced cardiomyopathy (CURE-PLaN)

The sarcoplasmic reticulum (SR) is a membrane-bound structure found within the cardiac muscle cells. Its main function is to regulate the flow of calcium, releasing calcium ions to the surrounding muscle fibers during contraction of the heart muscle and absorbing calcium during relaxation; calcium makes the heart pump. A crucial protein that regulates the function of the SR is phospholamban (PLN); mutations in the PLN gene result in defective PLN which can in turn causes a genetic, or inherited, form of heart failure.

The CURE-PLaN network will focus on one particular mutation that is found in patients in the United States and Europe. Our objective is to understand how patients with the mutation develop heart failure, and why not all patients with the mutation have the same clinical course.

Network scientists will use various models and single muscle cell lines to learn more about the genetics of the disease and how to alter the SR and PLN to make heart muscle cells work more efficiently. This network is funded by the Leducq Foundation and will work with the Dutch PLN Patient Foundation to focus on combatting PLN induced heart failure. Our ultimate goal is to cure PLN induced heart failure in humans.

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Meet our team

Meet our team

The CURE-PLan consortium consists of 2 Coordinators and 8 Principle Investigators. 21 Investigators will be involved during the course of the project.

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Meet our Team

Prof. dr. E. (Litsa) Kranias
Prof. dr. E. (Litsa) KraniasUS Coordinator
Prof. dr. P.A.F.M. (Pieter) Doevendans
Prof. dr. P.A.F.M. (Pieter) DoevendansEU Coordinator

For Patients

For Patients

The PLN disease is a currently uncurable heart muscle disease caused by a genetic mutation in the DNA. Carriers of this mutation are exposed to a major health risk which may express itself in moderate to very serious heart failure, arrhythmias and sudden premature death. The ultimate goal of all investigators united in CURE-PLaN is to cure PLN induced heart failure in humans.

PLN-Care Registry

PLN concerns an “orphan”-disease for which about a thousand carriers have been currently identified worldwide. It is of great importance for us to have as much data available of PLN-carriers and patients as possible. Please read more on the next pages in case you think you should be added to our PLN-Care Registry.

PLN Foundation

CURE-PLaN researchers collaborate closely with representatives of the PLN foundation. More information about the PLN foundation can be found here:

https://www.plnheart.org

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