Publications

Publications

Publications which acknowledge the Foundation Leducq support

✱ indicates collaboration between two or more members

2019

  1. Doevendans PA, Glijnis PC, Kranias Leducq Transatlantic Network of Excellence to Cure Phospholamban-Induced Cardiomyopathy (CURE-PLaN). Circ Res. 2019 Sep 13;125(7):720-724. doi: 10.1161/CIRCRESAHA.119.315077. Epub 2019 Sep 12 ✱
  2. Ikeda S, Mizushima W, Sciarretta S, Abdellatif M, Zhai P, Mukai R, Fefelova N, Oka SI, Nakamura M, Del Re DP, Farrance I, Park JY, Tian B, Xie LH, Kumar M, Hsu CP, Sadayappan S, Shimokawa H, Lim DS, Sadoshima J. Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload. Circ Res. 2019 Jan 18;124(2):292-305. doi: 10.1161/CIRCRESAHA.118.314048. PubMed PMID: 30582455; PubMed Central PMCID: PMC6645688.
  3. Te Rijdt WP, Asimaki A, Jongbloed JDH, Hoorntje ET, Lazzarini E, van der Zwaag PA, de Boer RA, van Tintelen JP, Saffitz JE, van den Berg MP, Suurmeijer AJH. Distinct molecular signature of phospholamban p.Arg14del arrhythmogenic cardiomyopathy. Cardiovasc Pathol. 2019 May – Jun;40:2-6. doi: 10.1016/j.carpath.2018.12.006. Epub 2018 Dec 21. PMID: 30763825 ✱
  4. Sadayappan S, Gilbert RJ. The potential role of neddylation in pre- and postnatal cardiac remodeling. Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H276-H278. doi: 10.1152/ajpheart.00260.2019. Epub 2019 Jul 5. PubMed PMID:
  5. Tabish AM, Arif M, Song T, Elbeck Z, Becker RC, Knoell R, Sadayappan S. Association of intronic DNA methylation and hydroxymethylation alterations in the epigenetic etiology of dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2019 Jul 1;317(1):H168-H180. doi: 10.1152/ajpheart.00758.2018. Epub 2019 Apr 26. PubMed PMID: 31026178.
  6. Vagnozzi RJ, Pfleger J and Sadayappan S. Basic Cardiovascular Sciences Scientific Sessions 2019: Integrative Approaches to Complex Cardiovascular Diseases. Circ Res. 2019 Oct 25;125(10):924-931 doi: 10.1161/CIRCRESAHA.119.315977 PMC6818742.

2020

  1. Becker RC, Sadayappan Designing human in vitro models for drug development. J Am Coll Cardiol. 2020 Feb 18;75(6):587-589. PMID:32057372.
  2. Chowdhury SA, Warren CM, Simon JN, Ryba DM, Batra A, Varga P, Kranias EG, Tardiff JC, Solaro RJ, Wolska BM. Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere Linked Hypertrophic Cardiomyopathy Despite Persistent Increases in Myofilament Ca-Response. Frontiers in Physiology (In Press)
  3. Tim Eijgenraam, Bas J. Boukens, Cornelis J. Boogerd, E. Marloes Schouten, Kees W.A. van de Kolk, Nienke M. Stege, Wouter P. te Rijdt, Edgar T. Hoorntje, Paul A. van der Zwaag, Eva van Rooij, J. Peter van Tintelen, Maarten P. van den Berg, Peter van der Meer, Jolanda van der Velden, Herman H.W. Silljé, Rudolf A. de Boer. Standard heart failure therapy is not effective in a mouse model of phospholamban p.(Arg14del) cardiomyopathy. Submitted ✱
  4. Julia Menzel, Daniel Kownatzki-Danger, Sergiy Tolkar, Alice Ballone, Kirsten Unthan-Fechner, Markus Kilisch, Mattia Mori, Christian Ottmann, Michael J. Shattock, Stephan E. Lehnart, Blanche Schwappach. 14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban (Science Signaling, manuscript # aaz1436; In revision)
  5. Emilia Nagyova*, Edgar T. Hoorntje*, Wouter P. te Rijdt, Laurens P. Bosman, Petros Syrris, Alexandros Protonotarios, Perry M. Elliott, Adalena Tsatsopoulo, Luisa Mestroni, Yuko Wada, Minoru Horie, Jens Mogensen, Alex H. Christensen, Brenda Gerull, Lei Song, Yan Yao, Siyang Fan, Ardan M. Saguner M., Duru Firat, Juha W. Koskenvuo, Tania Cruz Marino, Cynthia A. James, Crystal Tichnell, Cristina Basso, Kalliopi Pilichou, Barbara Bauce, Arthur A Wilde, Philippe Charron, Folkert W. Asselbergs, Maarten P. van den Berg, Jan D.H. Jongbloed, Magdalena Harakalova, J. Peter van Tintelen A meta-analysis of the clinical outcome associated with multiple reclassified desmosomal gene variants in arrhythmogenic right ventricular cardiomyopathy. Submitted ✱
  6. Ortiz AC, Felice JI, Valverde CA, Federico M, Palomeque J, Wherens X, Kranias EG, Elena C. Lascano EC, Negroni JA, Mattiazzi A. Determinants of Ca2+ Release Restitution: Insights from Genertically Altered Animals and Mathematical Modeling (In revision)
  7. Raad N, Bittihn P, Cacheux M, Jeong D, Ilkan Z, Ceholski D, Kohlbrenner E, Cai C, Hajjar RJ, Kranias EG, Stillitano F, Akar FG. Arrhythmia Mechanism and Dynamics in a Novel Humanized Mouse Model of Arrhythmogenic Cardiomyopathy due to Phospholamban R14del Mutation (In Revision) ✱
  8. Withaar, L.M.G. Meems, H.H.W. Silljé, E.M. Schouten, A.A. Voors, M.M. Dokter, B.D. Westenbrink, C.S.P. Lam, R.A. de Boer. The cardioprotective and metabolic effects of Liraglutide and Dapagliflozin in a multifactorial mouse model of Heart Failure with Preserved Ejection Fraction. Submitted ✱

Other publications by network members related to the network program

 2018

Kranias EG, Doevendans PA, Glijnis PC, Hajjar RJ. PLN Foundation. Circ Res. 2018 Dec 7;123(12):1276-1278. doi: 10.1161/CIRCRESAHA.118.314014. No abstract available. PMID: 30566043

Mast TP, Taha K, Cramer MJ, Lumens J, van der Heijden JF, Bouma BJ, van den Berg MP, Asselbergs FW, Doevendans PA, Teske AJ. The Prognostic Value of Right Ventricular Deformation Imaging in Early Arrhythmogenic Right Ventricular Cardiomyopathy. JACC Cardiovasc Imaging. 2019 Mar;12(3):446-455. doi: 10.1016/j.jcmg.2018.01.012. Epub 2018 Mar 14. PMID: 29550307

2019

Corrado D, van Tintelen PJ, McKenna WJ, Hauer RNW, Anastastakis A, Asimaki A, Basso C, Bauce B, Brunckhorst C, Bucciarelli-Ducci C, Duru F, Elliott P, Hamilton RM, Haugaa KH, James CA, Judge D, Link MS, Marchlinski FE, Mazzanti A, Mestroni L, Pantazis A, Pelliccia A, Marra MP, Pilichou K, Platonov PGA, Protonotarios A, Rampazzo A, Saffitz JE, Saguner AM, Schmied C, Sharma S, Tandri H, Te Riele ASJM, Thiene G, Tsatsopoulou A, Zareba W, Zorzi A, Wichter T, Marcus FI, Calkins H; International Experts . Arrhythmogenic right ventricular cardiomyopathy: evaluation of the current diagnostic criteria and differential diagnosis. Eur Heart J. 2019 Oct 21. pii: ehz669. doi: 10.1093/eurheartj/ehz669. [Epub ahead of print] PubMed PMID: 31637441.

Alsina KM, Hulsurkar M, Brandenburg S, Kownatzki-Danger D, Lenz C, Urlaub H, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick AP, Scott L Jr, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Lehnart SE, Wehrens XHT. Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation. Circulation. 2019 Aug 20;140(8):681-693. PMID: 31185731

Brandenburg S, Pawlowitz J, Eikenbusch B, Peper J, Kohl T, Mitronova GY, Sossalla S, Hasenfuss G, Wehrens XH, Kohl P, Rog-Zielinska EA, Lehnart SE. Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis. JCI Insight. 2019 Jun 20; 4(12). pii: 127116. PMID: 31217359

Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettilä V, Stridsberg M, Lehnart SE, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, Røsjø H, Louch WE. Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia. Circ Arrhythm Electrophysiol. 2019 Apr; 12(4): e007045. PMID: 30943765

van den Hoogen P, de Jager SCA, Mol EA, Schoneveld AS, Huibers MMH, Vink A, Doevendans PA, Laman JD, Sluijter JPG. Potential of mesenchymal- and cardiac progenitor cells for therapeutic targeting of B-cells and antibody responses in end-stage heart failure. PLoS One. 2019 Dec 31;14(12):e0227283. doi: 10.1371/journal.pone.0227283. eCollection 2019. PMID: 31891633

van den Hoogen P, de Jager SCA, Huibers MMH, Schoneveld AH, Puspitasari YM, Valstar GB, Oerlemans MIFJ, de Weger RA, Doevendans PA, den Ruijter HM, Laman JD, Vink A, Sluijter JPG. Increased circulating IgG levels, myocardial immune cells and IgG deposits support a role for an immune response in pre- and end-stage heart failure. J Cell Mol Med. 2019 Nov;23(11):7505-7516. doi: 10.1111/jcmm.14619. Epub 2019 Sep 26. PMID: 31557411

Zweerink A, Salden OAE, van Everdingen WM, de Roest GJ, van de Ven PM, Cramer MJ, Doevendans PA, van Rossum AC, Vernooy K, Prinzen FW, Meine M, Allaart CP. Hemodynamic Optimization in Cardiac Resynchronization Therapy: Should We Aim for dP/dtmax or Stroke Work? JACC Clin Electrophysiol. 2019 Sep;5(9):1013-1025. doi: 10.1016/j.jacep.2019.05.020. Epub 2019 Jul 31. PMID: 31537329

Bracco Gartner TCL, Deddens JC, Mol EA, Magin Ferrer M, van Laake LW, Bouten CVC, Khademhosseini A, Doevendans PA, Suyker WJL, Sluijter JPG, Hjortnaes J. Anti-fibrotic Effects of Cardiac Progenitor Cells in a 3D-Model of Human Cardiac Fibrosis. Front Cardiovasc Med. 2019 Apr 26;6:52. doi: 10.3389/fcvm.2019.00052. eCollection 2019. PMID: 31080805

Hof IE, van der Heijden JF, Kranias EG, Sanoudou D, de Boer RA, van Tintelen JP, van der Zwaag PA, Doevendans PA. Prevalence and cardiac phenotype of patients with a phospholamban mutation. Neth Heart J. 2019 Feb; 27(2):64-69. PMID: 300547415 ✱

Valverde CA, Mazzocchi G, Di Carlo MN, Ciocci Pardo A, Salas N, Ines Ragone M, Felice JI, Cely-Ortiz A, Consolini AE, Portiansky E, Mosca S, Kranias EG, Wehrens XHT, Mattiazzi A. Ablation of PLN rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors. Cardiovasc Res. 2019 Mar 1 [Epub ahead of print]. PMID: 30169578

Gardner GT, Travers JG, Qian J, Liu G-S, Haghighi K, Robbins NJ, Jiang M, Li Y,  Fan G-C, Rubinstein J, Blaxall BC, Kranias EG: Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure. JACC Basic Transl Sci. 2019 Apr 29;4(2):188-199. PMID: 31061921

Essandoh K, Wang X, Huang W, Deng S, Gardner G, Mu X, Li Y, Kranias EG, Wang Y, Fan GC. Tumor susceptibility gene 101 ameliorates endotoxin-induced cardiac dysfunction by enhancing Parkin-mediated mitophagy. J. Biol. Chem. 2019; 294:18057-18068. First Published On October 16, 2019. doi:10.1074/jbc.RA119.008925; PMID:31619520

Efentakis P, Varela A, Chavdoula E, Sigala F, Sanoudou D, Tenta R, Gioti K, Kostomitsopoulos N, Papapetropoulos A, Tasouli A, Farmakis D, Davos CH, Klinakis A, Suter T, Cokkinos DV, Iliodromitis EK, Wenzel P, Andreadou I. Levosimendan prevents doxorubicin-induced cardiotoxicity in time- and dose dependent manner: Implications for inotropy.Cardiovasc Res. 2019 Jun 22. pii: cvz163. doi: 10.1093/cvr/cvz163.

Chow MZ, Sadrian SN, Keung W, Geng L, Ren L, Kong CW, Wong AO, Hulot JS, Chen CS, Costa KD, Hajjar RJ, Li RA. Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues. Sci Rep. 9(1):7502, 2019.

Keung W, Chan PKW, Backeris PC, Lee EK, Wong N, Wong AOT, Wong GKY, Chan CWY, Fermini B, Costa KD, Li RA. Human cardiac ventricular-like organoid chambers and tissue strips from pluripotent stem cells as a two-tiered assay for inotropic responses: a blinded validation.  Clin Pharmacol Ther. 106(2):402-414, 2019.

Wong AO, Wong G, Shen M, Chow MZ, Tse WW, Gurung B, Mak SY, Lieu DK, Costa KD, Chan CW, Martelli A, Nabhan JF, Li RA. Correlation between frataxin expression and contractility revealed by in vitro Friedreich’s ataxia cardiac tissue models engineered from human pluripotent stem cells. Stem Cell Res Ther. Jul 8;10(1):203, 2019.

Li S, Chopra A, Keung W, Chan C, Costa KD, Kong CW, Hajjar RJ, Chen C, Li R. Sarco/Endoplasmic Reticulum Ca2+-ATPase is a more effective calcium remover than sodium-calcium exchanger in human embryonic stem cell-derived cardiomyocytes. Am J Physiol Heart Circ Physiol. 317(5):H1105-H1115, 2019.

Murphy JF, Mayourian J, Stillitano F, Munawar S, Broughton KM, Agullo-Pascual E, Sussman MA, Hajjar RJ, Costa KD, Turnbull IC.  Adult human cardiac stem cell supplementation effectively increases contractile function and maturation in human engineered cardiac tissues. Stem Cell Res Ther. Dec 4;10(1):373, 2019.

Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettilä V, Stridsberg M, Lehnart SE, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, Røsjø H, Louch WE (2019) Secretoneurin is an endogenous calcium/calmodulin-dependent protein kinase II inhibitor that attenuates Ca2+-dependent arrhythmia. Circ Arrhythm Electrophysiol. 12(4):e007045. doi: 10.1161/CIRCEP.118.007045. 2019 PMID 30943765

Alsina KM, Hulsurkar M, Brandenburg S, Kownatzki-Danger D, Lenz C, Urlaub H, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick AP, Scott L Jr, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Lehnart SE*, Wehrens XHT* (2019) Loss of protein phosphatase 1 regulatory subunit PPP1R3A promotes atrial fibrillation. Circulation 140(8): 681-693. PMID 31185731; 2019 *corresponding authors

Brandenburg S, Pawlowitz J, Eikenbusch B, Peper J, Kohl T, Mitronova GY, Sossalla S, Hasenfuss G, Wehrens XH, Kohl P, Rog-Zielinska EA, Lehnart SE (2019) Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis. JCI Insight 4(12). pii: 127116. 2019 PMID 31217359

Taha K, Mast TP, Cramer MJ, van der Heijden JF, Asselbergs FW, Doevendans PA, Teske AJ. Evaluation of Disease Progression in Arrhythmogenic Cardiomyopathy: The Change of Echocardiographic Deformation Characteristics Over Time. JACC Cardiovasc Imaging. 2020 Feb;13(2 Pt 2):631-634. doi: 10.1016/j.jcmg.2019.08.014. Epub 2019 Oct 11. No abstract available. PMID: 31607671

van Heesch S, Witte F, Schneider-Lunitz V, Schulz JF, Adami E, Faber AB, Kirchner M, Maatz H, Blachut S, Sandmann CL, Kanda M, Worth CL, Schafer S, Calviello L, Merriott R, Patone G, Hummel O, Wyler E, Obermayer B, Mücke MB, Lindberg EL, Trnka F, Memczak S, Schilling M, Felkin LE, Barton PJR, Quaife NM, Vanezis K, Diecke S, Mukai M, Mah N, Oh SJ, Kurtz A, Schramm C, Schwinge D, Sebode M, Harakalova M, Asselbergs FW, Vink A, de Weger RA, Viswanathan S, Widjaja AA, Gärtner-Rommel A, Milting H, Dos Remedios C, Knosalla C, Mertins P, Landthaler M, Vingron M, Linke WA, Seidman JG, Seidman CE, Rajewsky N, Ohler U, Cook SA, Hubner N. The Translational Landscape of the Human Heart. Cell. 2019 Jun 27;178(1):242-260.e29. doi: 10.1016/j.cell.2019.05.010. Epub 2019 May 30.

Manduchi E, Hemerich D, van Setten J, Tragante V, Harakalova M, Pei J, Williams SM, van der Harst P, Asselbergs FW, Moore JH. A comparison of two workflows for regulome and transcriptome-based prioritization of genetic variants associated with myocardial mass. Genet Epidemiol. 2019 Sep;43(6):717-726. doi: 10.1002/gepi.22215. Epub 2019 May 30.

Sammani A, Jansen M, Linschoten M, Bagheri A, de Jonge N, Kirkels H, van Laake LW, Vink A, van Tintelen JP, Dooijes D, Te Riele ASJM, Harakalova M, Baas AF, Asselbergs FW. UNRAVEL: big data analytics research data platform to improve care of patients with cardiomyopathies using routine electronic health records and standardised biobanking. Neth Heart J. 2019 Sep;27(9):426-434. doi: 10.1007/s12471-019-1288-4.

Bosman LP, Verstraelen TE, van Lint FHM, Cox MGPJ, Groeneweg JA, Mast TP, van der Zwaag PA, Volders PGA, Evertz R, Wong L, de Groot NMS, Zeppenfeld K, van der Heijden JF, van den Berg MP, Wilde AAM, Asselbergs FW, Hauer RNW, Te Riele ASJM, van Tintelen JP; Netherlands ACM Registry. The Netherlands Arrhythmogenic Cardiomyopathy Registry: design and status update. Neth Heart J. 2019 Oct;27(10):480-486. doi: 10.1007/s12471-019-1270-1.

2020

Spee RF, Niemeijer VM, Schoots T, Tuinenburg A, Houthuizen P, Wijn PF, Doevendans PA, Kemps HM. High intensity interval training after cardiac resynchronization therapy: An explorative randomized controlled trial. Int J Cardiol. 2020 Jan 15;299:169-174. doi: 10.1016/j.ijcard.2019.07.023. Epub 2019 Jul 12. PMID: 31353158

Oh JG, Dave J, Kho C, Stillitano F. Generation of Ventricular-Like HiPSC-Derived Cardiomyocytes and High-Quality Cell Preparations for Calcium Handling Characterization. J. Vis. Exp. (155), e60135, 2020.

Shah S, Henry A, Roselli C, Lin H, Sveinbjörnsson G, Fatemifar G, Hedman ÅK, Wilk JB, Morley MP, Chaffin MD, Helgadottir A, Verweij N, Dehghan A, Almgren P, Andersson C, Aragam KG, Ärnlöv J, Backman JD, Biggs ML, Bloom HL, Brandimarto J, Brown MR, Buckbinder L, Carey DJ, Chasman DI, Chen X, Chen X, Chung J, Chutkow W, Cook JP, Delgado GE, Denaxas S, Doney AS, Dörr M, Dudley SC, Dunn ME, Engström G, Esko T, Felix SB, Finan C, Ford I, Ghanbari M, Ghasemi S, Giedraitis V, Giulianini F, Gottdiener JS, Gross S, Guðbjartsson DF, Gutmann R, Haggerty CM, van der Harst P, Hyde CL, Ingelsson E, Jukema JW, Kavousi M, Khaw KT, Kleber ME, Køber L, Koekemoer A, Langenberg C, Lind L, Lindgren CM, London B, Lotta LA, Lovering RC, Luan J, Magnusson P, Mahajan A, Margulies KB, März W, Melander O, Mordi IR, Morgan T, Morris AD, Morris AP, Morrison AC, Nagle MW, Nelson CP, Niessner A, Niiranen T, O’Donoghue ML, Owens AT, Palmer CNA, Parry HM, Perola M, Portilla-Fernandez E, Psaty BM; Regeneron Genetics Center, Rice KM, Ridker PM, Romaine SPR, Rotter JI, Salo P, Salomaa V, van Setten J, Shalaby AA, Smelser DT, Smith NL, Stender S, Stott DJ, Svensson P, Tammesoo ML, Taylor KD, Teder-Laving M, Teumer A, Thorgeirsson G, Thorsteinsdottir U, Torp-Pedersen C, Trompet S, Tyl B, Uitterlinden AG, Veluchamy A, Völker U, Voors AA, Wang X, Wareham NJ, Waterworth D, Weeke PE, Weiss R, Wiggins KL, Xing H, Yerges-Armstrong LM, Yu B, Zannad F, Zhao JH, Hemingway H, Samani NJ, McMurray JJV, Yang J, Visscher PM, Newton-Cheh C, Malarstig A, Holm H, Lubitz SA, Sattar N, Holmes MV, Cappola TP, Asselbergs FW, Hingorani AD, Kuchenbaecker K, Ellinor PT, Lang CC, Stefansson K, Smith JG, Vasan RS, Swerdlow DI, Lumbers RT. Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. Nat Commun. 2020 Jan 9;11(1):163. doi: 10.1038/s41467-019-13690-5.